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Home Antibody All anti-TBP antibodies

Anti-TBP Antibody EPR3826(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA311083
  • Rabbit Monoclonal antibody against TFIID (TBP)
100ul 325 3-7 Days
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WB(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TFIID was used as an immunogen.
Clone NameEPR3826(2) IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:100 - 1:500
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens TATA box binding protein (TBP), transcript variant 2
Alternative NameGTF2D; GTF2D1; HDL4; SCA17; TFIID
Database LinkNP_001165556
FunctionInitiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. TFIID, a transcription factor, coordinates these activities and binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. It is TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. TFIID is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease (1).
Related Pathway
Wnt Signaling Pathway

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WB Image
Western blot - Anti-TATA binding protein TBP antibody [EPR3826(2)]; All lanes : Anti-TATA binding protein TBP antibody [EPR3826(2)] at 1/1000 dilution.Lane 1 : PC12 cell lysate.Lane 2 : F9 cell lysate.Lane 3 : K562 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 38 kDa.Observed band size : 36 kDa .
FC Image
Flow Cytometry - Anti-TATA binding protein TBP antibody [EPR3826(2)]; TA311083 at 1/50 dilution staining TATA binding protein TBP in permeabilized K562 cells by Flow cytometry (red) or a rabbit IgG negative control (green).

 

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