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Home Antibody All anti-OS9 antibodies

Anti-OS9 Antibody EPR4272(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA311017
  • Rabbit Monoclonal antibody against OS-9 (OS9)
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human OS-9 was used as an immunogen.
Clone NameEPR4272(2) IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens osteosarcoma amplified 9, endoplasmic reticulum lectin (OS9), transcript variant 2
Alternative NameERLEC2; OS-9
Database LinkNP_001017956
FunctionOS-9 is a lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). It binds terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation (1). OS-9 is highly expressed in osteosarcomas, which binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits (2).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - OS9 antibody [EPR4272(2)]; All lanes : Anti-OS9 antibody [EPR4272(2)] at 1/10000 dilution.Lane 1 : NIH3T3 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : HL-60 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 76 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - OS9 antibody [EPR4272(2)]; Immunohistochemical analysis of paraffin-embedded Mouse testis tissue using TA311017 at a dilution of 1/100.

 

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