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Anti-JAK1 Antibody EPR349(N)
Also for JAK1 (NM_002227)
|A synthetic peptide corresponding to residues in human JAK1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens Janus kinase 1 (JAK1)|
|JAK1A; JAK1B; JTK3|
Entrez Gene 3716 Human
Entrez Gene 16451 Mouse
Entrez Gene 84598 Rat
|Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs (1). |
|Protein KinaseDruggable Genome Jak-STAT signaling pathwayPathways in cancerPancreatic cancer|
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Western blot - Anti-JAK1 antibody [EPR349(N)]; All lanes : Anti-JAK1 antibody [EPR349(N)] at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : HT-29 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 133 kDa.