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Anti-FOXO4 PHOSPHO Antibody EPR2315(2)
Also for FOXO4 (NM_005938)
|A phospho specific peptide corresponding to residues surrounding serine 262 of human FOXO4 was used as an immunogen. This antibody only detects FOXO4 phosphorylated at serine 262.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:10000 - 1:50000
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens forkhead box O4 (FOXO4), transcript variant 1|
|AFX; AFX1; MLLT7|
|FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2). |
TGF Beta Signaling Pathway
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Western blot - Anti-FOXO4 (phospho S262) antibody [EPR2315(2)]; All lanes : Anti-FOXO4 (phospho S262) antibody [EPR2315(2)] at 1/10000 dilution.Lane 1 : Cell lysate from FOXO4 transfected 293T.Lane 2 : Cell lysate from FOXO4 transfected 293T treated with Alkaline Phosphatase.Lane 3 : Cell lysate from non-transfected 293T.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.
Other-Anti-FOXO4 (phospho S262) antibody [EPR2315(2)](TA310500); Equilibrium disassociation constant (KD)..