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Home Antibody All anti-CTSL1 antibodies

Anti-CTSL1 Antibody EPR8011


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310377 Rabbit Monoclonal antibody against Cathepsin L1 (CTSL1) 100ul $325 In Stock
LC407805 CTSL HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for CTSL1 (NM_145918)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Cathepsin L1 was used as an immunogen.
Clone NameEPR8011 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC, IF Suggested DilutionsICC/IF: Use at an assay dependent concentration; WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100
Predicted MW Explanation 38 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens cathepsin L (CTSL), transcript variant 2
Alternative NameCATL; CTSL1; MEP
Database LinkNP_666023
Entrez Gene 1514 Human
Entrez Gene 13039 Mouse
Entrez Gene 25697 Rat
FunctionCathepsin L1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L1 has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor (1).
Related PathwayProteaseDruggable Genome LysosomeAntigen processing and presentation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Cathepsin L antibody [EPR8011]; All lanes : Anti-Cathepsin L antibody [EPR8011] at 1/1000 dilution.Lane 1 : A549 cell lysate.Lane 2 : HCT-116 cell lysate.Lane 3 : NIH/3T3 cell lysate.Lane 4 : PC-12 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 38 kDa.

WB Image
Western blot - Anti-Cathepsin L antibody [EPR8011]; Anti-Cathepsin L antibody [EPR8011] at 1/1000 dilution + HepG2 cell lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 38 kDa.

Assay Image
Other-Anti-Cathepsin L antibody [EPR8011](TA310377); Equilibrium disassociation constant (KD)..

IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin L antibody [EPR8011]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling Cathepsin L with TA310377 at 1/50 dilution.

IF Image
Immunocytochemistry/ Immunofluorescence - Anti-Cathepsin L antibody [EPR8011]; TA310377 stainingCathepsin LinHuman HepaRGcell by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed withformaldehyde, permeabilized with 0.1% Triton X-100 and blocked with 1%milk for 30 minutes at room temperature. Samples were incubated with primary antibody (1/1000) for30 minutes. AnAlexa Fluor?488-conjugated Donkey anti-rabbit IgG polyclonal (1/400) was used as the secondary antibody.


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