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Home Antibody All anti-CPN1 antibodies

Anti-CPN1 Antibody EPR6229


Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA310348 Rabbit Monoclonal antibody against CPN1 100ul $325 In Stock
LC420016 CPN1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart


OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CPN1 was used as an immunogen.
Clone NameEPR6229 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens carboxypeptidase N, polypeptide 1 (CPN1)
Alternative NameCPN; SCPN
Database LinkNP_001299
Entrez Gene 1369 Human
FunctionCarboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. CPN1 is important in the regulation of peptides like kinins and anaphylatoxins, and it has also been known as kininase-1 and anaphylatoxin inactivator. It is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; CPN1 is the catalytic subunit. Mutations in this protein can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency (1).
Note: The 48-kDa form is generated by proteolytic cleavage at the C-terminus. This subunit is cleaved into a peptide of 27 kDa (2).
Related PathwaySecreted ProteinProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-CPN1 antibody [EPR6229]; All lanes : Anti-CPN1 antibody [EPR6229] at 1/1000 dilution.Lane 1 : Human plasma lysate.Lane 2 : HepG2 lysate.Lane 3 : Human fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 52 kDa.Additional bands at : 27 kDa (possible cleavage fragment),48 kDa (possible cleavage fragment).


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