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Home Antibody All anti-CPN1 antibodies

Anti-CPN1 Antibody EPR6229


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310348 Rabbit Monoclonal antibody against CPN1 100ul $325 In Stock
LC420016 CPN1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CPN1 was used as an immunogen.
Clone NameEPR6229 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens carboxypeptidase N subunit 1 (CPN1)
Alternative NameCPN; SCPN
Database LinkNP_001299
Entrez Gene 1369 Human
FunctionCarboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. CPN1 is important in the regulation of peptides like kinins and anaphylatoxins, and it has also been known as kininase-1 and anaphylatoxin inactivator. It is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; CPN1 is the catalytic subunit. Mutations in this protein can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency (1).
Note: The 48-kDa form is generated by proteolytic cleavage at the C-terminus. This subunit is cleaved into a peptide of 27 kDa (2).
Related PathwaySecreted ProteinProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CPN1 antibody [EPR6229]; All lanes : Anti-CPN1 antibody [EPR6229] at 1/1000 dilution.Lane 1 : Human plasma lysate.Lane 2 : HepG2 lysate.Lane 3 : Human fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 52 kDa.Additional bands at : 27 kDa (possible cleavage fragment),48 kDa (possible cleavage fragment).


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