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Anti-CPN1 Antibody EPR6229
Also for CPN1 (NM_001308)
|A synthetic peptide corresponding to residues in human CPN1 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens carboxypeptidase N, polypeptide 1 (CPN1)|
|Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. CPN1 is important in the regulation of peptides like kinins and anaphylatoxins, and it has also been known as kininase-1 and anaphylatoxin inactivator. It is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; CPN1 is the catalytic subunit. Mutations in this protein can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency (1). |
Note: The 48-kDa form is generated by proteolytic cleavage at the C-terminus. This subunit is cleaved into a peptide of 27 kDa (2).
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Western blot - Anti-CPN1 antibody [EPR6229]; All lanes : Anti-CPN1 antibody [EPR6229] at 1/1000 dilution.Lane 1 : Human plasma lysate.Lane 2 : HepG2 lysate.Lane 3 : Human fetal liver lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 52 kDa.Additional bands at : 27 kDa (possible cleavage fragment),48 kDa (possible cleavage fragment).