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Anti-CFB Antibody EPR9288(B)
|A synthetic peptide corresponding to residues on the C-terminus in human Complement Factor B was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 48% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for IHC-P or IP.
|Homo sapiens complement factor B (CFB)|
|AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2|
Entrez Gene 629 Human
|Complement Factor B is a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Complement Factor B is linked to major histocompatibility complex (MHC) class III and is involved in the regulation of the immune reaction. Mutations in Complement Factor B are associated with a reduced risk of age-related macular degeneration (1).|
|Secreted ProteinProteaseDruggable Genome Complement and coagulation cascades|
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Western blot - Anti-Complement factor B antibody [EPR9288(B)]; All lanes : Anti-Complement factor B antibody [EPR9288(B)] at 1/1000 dilution.Lane 1 : Human serum lysate.Lane 2 : Human plasma lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 95 kDa .Additional bands at : 60 kDa (possible isoform).
Other-Anti-Complement factor B antibody [EPR9288(B)](TA310318); Equilibrium disassociation constant (KD)..