Home Antibody All anti-BMPR2 antibodies
Also for BMPR2 (NM_001204)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 667 and 921 of Human BMPR2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)|
|BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK|
Entrez Gene 659 Human
Entrez Gene 12168 Mouse
|This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq]|
|Protein KinaseTransmembraneDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway|
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Sample(30 ug of whole cell lysate) A:H1299 B:Raji (anti-BMPR2 antibody diluted at 1:1000)