Home Antibody All anti-ACMSD antibodies
Also for ACMSD (NM_138326)
|Recombinant fragment corresponding to a region within amino acids 105 and 336 of ACMSD (Uniprot ID#Q8TDX5)|
|Human, Mouse (Predicted: Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Bovine (93%)
|Homo sapiens aminocarboxymuconate semialdehyde decarboxylase (ACMSD)|
|2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; OTTHUMP00000162500; aminocarboxymuconate semialdehyde decarboxylase|
Entrez Gene 130013 Human
Entrez Gene 266645 Mouse
|The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 220.127.116.11) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM]|
|Transmembrane Tryptophan metabolismMetabolic pathways|
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Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308027 diluted at 1:1000.
Sample (30 ug of whole cell lysate). A: Molt-4 . B: Raji. 10% SDS PAGE. TA308027 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded SAS xenograft, using ACMSD(TA308027) antibody at 1:100 dilution.