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Home Antibody All anti-IL12RB2 antibodies

Anti-IL12RB2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307956 Rabbit polyclonal antibody to IL-12 Receptor beta2 (interleukin 12 receptor, beta 2) 100ul $325 3-7 Days
LC400597 IL12RB2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 323 and 695 of IL-12 Receptor beta2 (Uniprot ID#Q99665)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Dog) Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:1000-1:10000
Predicted MW Explanation 97kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (80%)

Reference Data

Target NameHomo sapiens interleukin 12 receptor, beta 2 (IL12RB2), transcript variant 1
Alternative NameRP11-102M16.1
Database LinkNP_001550
Entrez Gene 3595 Human
Entrez Gene 489550 Dog
FunctionThe protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample(30 ug whole cell lysate). A:A431. B: Hep G2 . 7.5% SDS PAGE. TA307956 diluted at 1:5000


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