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Home Antibody All anti-PSEN2 antibodies

Anti-PSEN2 PHOSPHO Antibody EP2614

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307706
  • Rabbit monoclonal antibody against Presenilin 2 Phospho (pS330) (clone EP2614 ) (Phospho-Specific)
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Serine 330 in human Presenilin-2 was used as an immunogen. The antibody only detects Presenilin-2 phosphorylated on Serine 330.
Clone NameEP2614 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens presenilin 2 (PSEN2), transcript variant 1
Alternative NameAD3L; AD4; CMD1V; PS2; STM2
Database LinkNP_000438
FunctionPresenilin 1 (PS1) and Presenilin 2 (PS2) are transmembrane proteins which belong to Presenilin family, and their mutations are associated with early onset familial Alzheimer's disease. Presenilins facilitate gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Phosphorylation of the PS2 C-terminal fragments at serine residues 327 and 330, located immediately adjacent to the caspase recognition sites, inhibits caspase-mediated cleavage of PS2 and can regulate apoptotic cleavage. PS2 is cleaved by caspases during apoptosis between aspartate 329 and serine 330 (2).
Related Pathway
Delta-Notch Signaling Pathway

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WB Image
Western blot - Presenilin 2 (phospho S330) antibody [EP2614]; All lanes : Anti-Presenilin 2 (phospho S330) antibody [EP2614] at 1/5000 dilution.Lane 1 : HeLa cell lysate untreated with with Alkaline Phosphatase.Lane 2 : HeLa cell lysate treated with Alkaline Phosphatase.Lysates/proteins at 10 µg per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.

 

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