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Anti-PSEN2 PHOSPHO Antibody EP2614
Also for PSEN2 (NM_000447)
|A phospho-specific peptide corresponding to residues surrounding Serine 330 in human Presenilin-2 was used as an immunogen. The antibody only detects Presenilin-2 phosphorylated on Serine 330.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 1|
|AD3L; AD4; CMD1V; PS2; STM2|
|Presenilin 1 (PS1) and Presenilin 2 (PS2) are transmembrane proteins which belong to Presenilin family, and their mutations are associated with early onset familial Alzheimer's disease. Presenilins facilitate gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Phosphorylation of the PS2 C-terminal fragments at serine residues 327 and 330, located immediately adjacent to the caspase recognition sites, inhibits caspase-mediated cleavage of PS2 and can regulate apoptotic cleavage. PS2 is cleaved by caspases during apoptosis between aspartate 329 and serine 330 (2). |
Delta-Notch Signaling Pathway
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Western blot - Presenilin 2 (phospho S330) antibody [EP2614]; All lanes : Anti-Presenilin 2 (phospho S330) antibody [EP2614] at 1/5000 dilution.Lane 1 : HeLa cell lysate untreated with with Alkaline Phosphatase.Lane 2 : HeLa cell lysate treated with Alkaline Phosphatase.Lysates/proteins at 10 µg per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.