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Anti-ERBB4 PHOSPHO Antibody EPR2269
Also for ERBB4 (NM_005235)
|A phospho-specific peptide corresponding to residues surrounding Tyrosine 1056 in human HER4/ErbB4 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1,000 - 10,000,
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4), transcript variant JM-a/CVT-1|
|ALS19; HER4; p180erbB4|
|HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).|
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Western blot - ErbB 4 (phospho Y1056) antibody [EPR2269]; All lanes : Anti-ErbB 4 (phospho Y1056) antibody [EPR2269] at 1/1000 dilution.Lane 1 : A431 cell lysate (Untreated).Lane 2 : A431 cell lysate (Treated with Pervanadate).Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 147 kDa.