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Anti-FES Antibody EPR3230(2)
Also for FES (NM_001143783)
|A synthetic peptide corresponding to residues in human FES was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:100 - 1:500; ICC/IF: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for IHC-P.
|Homo sapiens feline sarcoma oncogene (FES), transcript variant 2|
|FES is a non-receptor protein-tyrosine kinase implicated in myeloid, vascular endothelial and neuronal cell differentiation. Closely related to FER, FES is characterized by a unique amino-terminal region (critical for kinase regulation and downstream signaling), a central SH2 domain, and a carboxyl-terminal kinase domain (1, 2). FES lacks an SH3 domain, a negative regulatory tail, and other features that contribute to negative regulation of c-Src, c-Abl, and other cytoplasmic tyrosine kinases. FES activation in response to growth factors and cytokines has been linked to various cellular events including survival, proliferation, differentiation, and reorganization of the cytoskeleton. FES has been implicated as a tumor suppressor in colorectal cancer (3).|
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Western blot - FES antibody [EPR3230(2)]; All lanes : Anti-FES antibody [EPR3230(2)] at 1/1000 dilution.Lane 1 : TF-1 lysate.Lane 2 : U937 lysate.Lane 3 : Human spleen lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 93 kDa.
Immunocytochemistry/ Immunofluorescence - FES antibody [EPR3230(2)]; ab108418, at a 1/100 dilution, staining FES in HeLa cells by Immunofluorescence.