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Anti-CTSD Antibody EPR3054
Also for CTSD (NM_001909)
|A synthetic peptide corresponding to residues on human Cathepsin D was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:2000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:250 - 1:500
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens cathepsin D (CTSD)|
|CLN10; CPSD; HEL-S-130P|
Entrez Gene 1509 Human
|Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5). |
|ProteaseDruggable Genome Lysosome|
* Availability is in business days
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Western blot - Anti-Cathepsin D antibody [EPR3054]; All lanes : Anti-Cathepsin D antibody [EPR3054] at 1/2000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : A431 cell lysate.Lane 3 : SKBR3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.developed using the ECL technique.Predicted band size : 44 kDa.
Other-Anti-Cathepsin D antibody [EPR3054](TA307500); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin D antibody [EPR3054]; Immunohistochemical analysis of paraffin-embedded Human breast ductal infiltrating carcinoma tissue, staining Cathepsin D using TA307500 at a 1/250 dilution.