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Home Antibody All anti-CTSD antibodies

Anti-CTSD Antibody EPR3054

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307500
  • Rabbit monoclonal antibody against Cathepsin D (clone EPR3054 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400712) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
Assay(1)
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Also for CTSD (NM_001909)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on human Cathepsin D was used as an immunogen.
Clone NameEPR3054 IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:2000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens cathepsin D (CTSD)
Alternative NameCLN10; CPSD; HEL-S-130P
Database LinkNP_001900
FunctionCathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43 kDa) is cleaved and glycosylated to form procathepsin D (46 kDa), and then further cleaved, forming light and a heavy chains (15 kDa and 28 kDa, respectively) (5).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Cathepsin D antibody [EPR3054]; All lanes : Anti-Cathepsin D antibody [EPR3054] at 1/2000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : A431 cell lysate.Lane 3 : SKBR3 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.developed using the ECL technique.Predicted band size : 44 kDa.
Assay Image
Other-Anti-Cathepsin D antibody [EPR3054](TA307500); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cathepsin D antibody [EPR3054]; Immunohistochemical analysis of paraffin-embedded Human breast ductal infiltrating carcinoma tissue, staining Cathepsin D using TA307500 at a 1/250 dilution.

 

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