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Anti-PRKACG Antibody EP2647Y
Also for PRKACG (NM_002732)
|A synthetic peptide corresponding to residues near the C-terminus of human PKA C gamma was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000 - 1:200000; IP: 1:10 - 1:100; FC: 1:100 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC/IF or IHC-P.
|Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma (PRKACG)|
|PKA (or cAPK) is a cyclic AMP-dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, and gene transcription (1, 2). PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states (2, 3). C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue-specific expression of C gamma, suggests a pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP-dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits (4).|
Hedgehog signaling pathway
MAPK signaling pathway
Wnt Signaling Pathway
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Western blot - PKA gamma (catalytic subunit) antibody [EP2647Y]; All lanes : Anti-PKA gamma (catalytic subunit) antibody [EP2647Y] at 1/50000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : PC3 cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 40 kDa.Observed band size : 40 kDa.