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Anti-PRKACG Antibody EP2647Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against PKA C gamma(clone EP2647Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419142) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human PKA C gamma was used as an immunogen.
Clone NameEP2647Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:50000 - 1:200000; IP: 1:10 - 1:100; FC: 1:100 - 1:500
Predicted MW Explanation 40 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens protein kinase, cAMP-dependent, catalytic, gamma (PRKACG)
Alternative NameBDPLT19; KAPG; PKACg
Database LinkNP_002723
Entrez Gene 5568 Human
FunctionPKA (or cAPK) is a cyclic AMP-dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, and gene transcription (1, 2). PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states (2, 3). C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue-specific expression of C gamma, suggests a pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP-dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits (4).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayCalcium signaling pathwayChemokine signaling pathwayOocyte meiosisApoptosisVascular smooth muscle contractionMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PKA gamma (catalytic subunit) antibody [EP2647Y]; All lanes : Anti-PKA gamma (catalytic subunit) antibody [EP2647Y] at 1/50000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : MCF7 cell lysate.Lane 3 : PC3 cell lysate.Lane 4 : A549 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 40 kDa.Observed band size : 40 kDa.


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