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Home Antibody All anti-RUVBL1 antibodies

Anti-RUVBL1 Antibody EPR4143


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against RUVBL1(clone EPR4143)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418487) , 20ug Explanation
100ul $325 3 Weeks
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Also for RUVBL1 (NM_003707)
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RUVBL1 was used as an immunogen.
Clone NameEPR4143 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Predicted MW Explanation 50 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens RuvB-like AAA ATPase 1 (RUVBL1)
Alternative NameECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A
Database LinkNP_003698
Entrez Gene 8607 Human
Entrez Gene 56505 Mouse
Entrez Gene 65137 Rat
FunctionRUVBL1, also known as TIP49A, is a member of the AAA+ family and component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (1, 2, 3). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins, positively regulating transcription (2). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest and replicative senescence; apoptosis; and double-strand break repair (2). RUVBL1 is ubiquitously expressed with high expression in the heart, skeletal muscle and testis (2).
Related PathwayStem cell - PluripotencyTranscription Factors Wnt signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TIP49A antibody [EPR4143]; All lanes : Anti-TIP49A antibody [EPR4143] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 50 kDa.


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