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Home Antibody All anti-GRB7 antibodies

Anti-GRB7 Antibody EPR4378

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307229
  • Rabbit monoclonal antibody against GRB7(clone EPR4378)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401639) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human GRB7 was used as an immunogen.
Clone NameEPR4378 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100
Predicted MW Explanation 60 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens growth factor receptor-bound protein 7 (GRB7), transcript variant 1
Alternative NameOTTHUMP00000164352; growth factor receptor-bound protein 7
Database LinkNP_005301
Entrez Gene 2886 Human
Entrez Gene 14786 Mouse
Entrez Gene 84427 Rat
FunctionGRB7 (Growth factor receptor-bound protein 7) belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. It interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein also plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK) (1). Best known for its regulatory role in cell migration and tumor metastasis, GRB7 regulates inflammation by coupling NF-kappaB-inducing kinase with erbB/EGFR family receptors (2). The role of Grb7 in these processes depends upon binding to membrane-associated tyrosine kinases through its C-terminal SH2 domain (2). Aberrant overexpression of GRB7 has been found in numerous human cancers, including ovarian cancer (3).
Related PathwayStem cell - PluripotencyEmbryonic stem cellsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - GRB7 antibody [EPR4378]; All lanes : Anti-GRB7 antibody [EPR4378] at 1/1000 dilution.Lane 1 : SKBR-3 cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled Goat anti-Rabbit at 1/2000 dilution.Predicted band size : 60 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GRB7 antibody [EPR4378]; TA307229 at 1/50 dilution staining GRB7 in paraffin-embedded Human breast tissue by Immunohistochemistry.

 

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