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Anti-FRAT1 Antibody EPR3900
Also for FRAT1 (NM_005479)
|A synthetic peptide corresponding to residues in human FRAT1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC: 1:100 - 1:250; FC: 1:500 - 1:1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for IHC-P.
|Homo sapiens frequently rearranged in advanced T-cell lymphomas (FRAT1)|
|FRAT1 (frequently rearranged in advanced T-cell lymphomas) belongs to the GSK-3-binding protein family. This protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway (1). By binding to GSK3, FRAT1 prevents the phosphorylation and concomitant degradation of beta-catenin; this allows the activation of downstream targets by beta-catenin/TCF complexes (2). It may function in tumor progression and lymphomagenesis (1).|
Wnt Signaling Pathway
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Western blot - FRAT1 antibody [EPR3900]; All lanes : Anti-FRAT1 antibody [EPR3900] at 1/1000 dilution.Lane 1 : HeLa cell lysate .Lane 2 : MCF7 cell lysate .Lysates/proteins at 10 µg per lane.Predicted band size : 29 kDa.