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Home Antibody All anti-PDGFRA antibodies

Anti-PDGFRA PHOSPHO Antibody EP2478

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307172
  • Rabbit monoclonal antibody against PDGF Receptor alpha Phospho (pY720)(clone EP2478) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
FC(1)
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Also for PDGFRA (NM_006206)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Tyrosine 720 of human PDGF Receptor alpha was used as an immunogen. This antibody only detects PDGF Receptor alpha phosphorylated at Tyrosine 720.
Clone NameEP2478 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:500 - 1:1000
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)
Alternative NameCD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Database LinkNP_006197
FunctionPDGF Receptor alpha is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development. Mice heterozygous for the receptor exhibit defective kidney phenotypes. Moreover, the SH2 domain of Shf can bind to PDGF Receptor alpha at tyrosine 720 (2).
Related Pathway
Cytokine-cytokine receptor interaction
Focal Adhesion
MAPK signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-PDGF Receptor alpha (phospho Y720) antibody [EP2478]; All lanes : Anti-PDGF Receptor alpha (phospho Y720) antibody [EP2478] at 1/1000 dilution.Lane 1 : NIH 3T3 cell lysate, untreated.Lane 2 : NIH 3T3 cell lysate, treated with Pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 122 kDa.Observed band size : 190 kDa .
FC Image
Flow Cytometry - Anti-PDGF Receptor alpha (phospho Y720) antibody [EP2478]; Flow Cytometry analysis of permeabilized NIH/3T3 cells labelling PDGF Receptor alpha (phospho Y720) with TA307172.Green - untreated, Red - pervanadate-treated, Blue - preincubated with phospho-PDGF Receptor alpha (phospho Y720) peptide, Orange - preincubated with non-phospho-PDGR Receptor alpha peptide.

 

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