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Anti-GRIN1 Antibody EPR2481(2)
Also for GRIN1 (NM_007327)
|A synthetic peptide corresponding to residues in human NMDAR1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant NR1-3|
|GluN1; MRD8; NMDA1; NMDAR1; NR1|
Entrez Gene 2902 Human
Entrez Gene 14810 Mouse
Entrez Gene 24408 Rat
|The NMDA (N-methyl D-aspartate) receptor in the brain plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning (1). It mediates neuronal functions in glutamate neurotransmission and is involved in the cell surface targeting of NMDA receptors (2). NMDAR is composed of at least one obligatory NMDA receptor 1 (NR1) subunit and one or more NR2A-D subunits. NMDA is probably regulated by the C-terminal phosphorylation of an isoform of NR1 by PKC and dephosphorylated on Ser-897 by protein phosphatase 2A (PPP2CB) (2). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and NMDAR channel activity (2). A role for NMDAR1 in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of neurochemical studies in HD and the ability of NMDAR1 to mediate neuronal cell death (3).|
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Western blot - NMDAR1 antibody [EPR2481(2)]; Anti-NMDAR1 antibody [EPR2481(2)] at 1/1000 dilution + Human fetal brain cell lysate at 10 ug.Predicted band size : 105 kDa.Observed band size : 120 kDa .
Flow Cytometry - Anti-NMDAR1 antibody [EPR2481(2)]; Flow cytometric analysis of permeabilized SH-SY5Y cells using anti- NMDAR1 RabMAb (red) or a rabbit IgG (negative)(green).