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Home Antibody All anti-GRIN1 antibodies

Anti-GRIN1 Antibody EPR2481(2)

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307127
  • Rabbit monoclonal antibody against NMDAR1(clone EPR2481(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402129) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
FC(1)
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Also for GRIN1 (NM_007327)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NMDAR1 was used as an immunogen.
Clone NameEPR2481(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
Predicted MW Explanation 105 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1), transcript variant GluN1-1a
Alternative NameGluN1; MRD8; NMD-R1; NMDA1; NMDAR1; NR1
Database LinkNP_015566
Entrez Gene 2902 Human
Entrez Gene 14810 Mouse
Entrez Gene 24408 Rat
FunctionThe NMDA (N-methyl D-aspartate) receptor in the brain plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning (1). It mediates neuronal functions in glutamate neurotransmission and is involved in the cell surface targeting of NMDA receptors (2). NMDAR is composed of at least one obligatory NMDA receptor 1 (NR1) subunit and one or more NR2A-D subunits. NMDA is probably regulated by the C-terminal phosphorylation of an isoform of NR1 by PKC and dephosphorylated on Ser-897 by protein phosphatase 2A (PPP2CB) (2). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and NMDAR channel activity (2). A role for NMDAR1 in the molecular pathology underlying Huntington disease (HD) has been proposed on the basis of neurochemical studies in HD and the ability of NMDAR1 to mediate neuronal cell death (3).
Related PathwayTransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Calcium signaling pathwayNeuroactive ligand-receptor interactionLong-term potentiationAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)Huntington's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - NMDAR1 antibody [EPR2481(2)]; Anti-NMDAR1 antibody [EPR2481(2)] at 1/1000 dilution + Human fetal brain cell lysate at 10 ug.Predicted band size : 105 kDa.Observed band size : 120 kDa .
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Flow Cytometry - Anti-NMDAR1 antibody [EPR2481(2)]; Flow cytometric analysis of permeabilized SH-SY5Y cells using anti- NMDAR1 RabMAb (red) or a rabbit IgG (negative)(green).
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