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Anti-PAX5 Antibody EPR3729
Also for PAX5 (NM_016734)
|A synthetic peptide corresponding to residues in human PAX5 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1: 100 - 250, WB: 1: 1,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens paired box 5 (PAX5), transcript variant 1|
|The human paired box protein Pax-5 (PAX5) is a member of the paired box domain family of transcription factors that play a role in B-cell differentiation, neural development, and spermatogenesis (1). As a result, its expression is detected in the developing central nervous system (CNS) and testis (1). In particular, PAX5 is essential for maintaining the identity and function of mature B cells during late B lymphopoiesis (2). The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation (3). During B-cell differentiation, PAX5 interacts with DAXX, a bridge protein that helps PAX5 to function as both a transcriptional activator and a repressor (4). A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia (1).|
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Western blot - PAX5 antibody [EPR3729]; All lanes : Anti-PAX5 antibody [EPR3729] at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : Daudi cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 42 kDa.