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Anti-RPS6KA2 Antibody E202
Also for RPS6KA2 (NM_021135)
|A synthetic peptide corresponding to residues surrounding threonine 353 and threonine 356 of human RSK3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||ICC: 1:50, IHC: 1:50-1:100, IP: 1:100, WB: 1:1,000 - 20,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 2 (RPS6KA2), transcript variant 1|
|HU-2; MAPKAPK1C; p90-RSK3; pp90RSK3; RSK; RSK3; S6K-alpha; S6K-alpha2|
|Rsk-3 is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk-1, Rsk-2 and Rsk-3. These are broadly expressed serine/threonine protein kinases (1) that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). Rsk-3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets, and may have a unique upstream activator (3). Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).|
EGFR1 Signaling Pathway
MAPK signaling pathway
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Immunohistochemistry (Paraffin-embedded sections) - RSK3 (phospho T353 + T356) antibody [E202]; Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using TA307066 at 1/50 dilution.