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Anti-P2RY6 Antibody EPR3816
Also for P2RY6 (NM_176798)
|A synthetic peptide corresponding to residues in human P2Y6 was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||ICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:50, WB: 1:20,000 - 100,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 2|
|P2Y6 is a multi-pass membrane protein and P2Y receptor, belonging to the family of G-protein coupled receptor 1 (1). The P2Y family is composed of eight cloned and functionally defined subtypes, including five that are present in human tissues (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) (2). P2Y6 is expressed in human spleen, placenta, thymus, intestine, and blood leukocytes and is a receptor for extracellular UDP, UTP and ADP (1). It contributes to microglia activation and their later phagocytosis in CNS, and in the immune system, it participates in the secretion of interleukin (IL)-8 from monocytes and macrocytes. It has been suggested that P2Y6 may play a role in neuroinflammation in CNS (3). |
Signaling by GPCR
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Western blot - P2Y6 antibody [EPR3816]; All lanes : Anti-P2Y6 antibody [EPR3816] at 1/20000 dilution.Lane 1 : A549 cell lysate.Lane 2 : HACAT cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : Human spleen lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 36 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - P2Y6 antibody [EPR3816]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue (left-hand image) and Human liver tissue (right-hand image) using TA306990 at a dilution of 1/100.