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Anti-P2RY6 Antibody EPR3816


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against P2Y6 (clone EPR3816 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC406126) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human P2Y6 was used as an immunogen.
Clone NameEPR3816 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:50, WB: 1:20,000 - 100,000,
Predicted MW Explanation 36 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 2
Alternative NameP2Y6
Database LinkNP_789768
Entrez Gene 5031 Human
FunctionP2Y6 is a multi-pass membrane protein and P2Y receptor, belonging to the family of G-protein coupled receptor 1 (1). The P2Y family is composed of eight cloned and functionally defined subtypes, including five that are present in human tissues (P2Y1, P2Y2, P2Y4, P2Y6 and P2Y11) (2). P2Y6 is expressed in human spleen, placenta, thymus, intestine, and blood leukocytes and is a receptor for extracellular UDP, UTP and ADP (1). It contributes to microglia activation and their later phagocytosis in CNS, and in the immune system, it participates in the secretion of interleukin (IL)-8 from monocytes and macrocytes. It has been suggested that P2Y6 may play a role in neuroinflammation in CNS (3).
Related PathwayGPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - P2Y6 antibody [EPR3816]; All lanes : Anti-P2Y6 antibody [EPR3816] at 1/20000 dilution.Lane 1 : A549 cell lysate.Lane 2 : HACAT cell lysate.Lane 3 : HepG2 cell lysate.Lane 4 : Human spleen lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 36 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - P2Y6 antibody [EPR3816]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue (left-hand image) and Human liver tissue (right-hand image) using TA306990 at a dilution of 1/100.


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