Home Antibody All anti-CDC27 antibodies
Also for CDC27 (NM_001114091)
|APC3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human APC3.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens cell division cycle 27 (CDC27), transcript variant 1|
|ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E; HNUC; NUC2|
|Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC3, also known as CDC27, a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. APC3 contains a tetratricopeptide repeat (TPR) region and interacts with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1.|
TGF Beta Signaling Pathway
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Western blot analysis of APC3 in mouse liver tissue lysate with APC3 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of APC3 in rat liver tissue with APC3 antibody at 5 ug/mL.