Home Antibody All anti-POU5F1 antibodies
Also for POU5F1 (NM_002701)
|POU5F1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human POU5F1.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens POU class 5 homeobox 1 (POU5F1), transcript variant 1|
|Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4|
|POU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.|
Wnt Signaling Pathway
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Western blot analysis of POU5F1 in mouse liver tissue lysate with POU5F1 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of POU5F1 in rat liver tissue with POU5F1 antibody at 5 ugg/mL.