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Home Antibody All anti-ANO1 antibodies

Anti-ANO1 Antibody

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SKU Description Amount Price Availability*  
TA306851
  • Rabbit Polyclonal TMEM16A Antibody
100ug 325 In Stock
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WB(1)

OriGene Data

ImmunogenTMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens anoctamin 1, calcium activated chloride channel (ANO1), transcript variant 1
Alternative NameDOG1; ORAOV2; TAOS2; TMEM16A
Database LinkNP_060513
Entrez Gene 55107 Human
Entrez Gene 101772 Mouse
FunctionCalcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC’s include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle; mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.
Related PathwayTransmembrane

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WB Image
Western blot analysis of TMEM16A in A549 cell lysate with TMEM16A antibody at 1 µg/ml.

 

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