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Also for ANO1 (NM_018043)
|TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens anoctamin 1, calcium activated chloride channel (ANO1), transcript variant 1|
|DOG1; ORAOV2; TAOS2; TMEM16A|
Entrez Gene 55107 Human
Entrez Gene 101772 Mouse
|Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC’s include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle; mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.|
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Western blot analysis of TMEM16A in A549 cell lysate with TMEM16A antibody at 1 µg/ml.