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Home Antibody All anti-AP2M1 antibodies

Anti-AP2M1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306777 Chicken Polyclonal AP2M1 Antibody 100ug $325 3-7 Days
LC422484 AP2M1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for AP2M1 (NM_001025205)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenAP2M1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human AP2M1.
Clone Name IsotypeIgY
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens adaptor-related protein complex 2, mu 1 subunit (AP2M1), transcript variant 2
Alternative NameAP50; CLAPM1; mu2
Database LinkNP_001020376
Entrez Gene 1173 Human
Entrez Gene 11773 Mouse
Entrez Gene 116563 Rat
FunctionThe heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.
Related PathwayDruggable Genome EndocytosisHuntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of AP2M1 in human kidney tissue lysate with AP2M1 antibody at (A) 1 and (B) 2 ug/ml.
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Immunohistochemistry of AP2M1 in mouse kidney tissue with AP2M1 antibody at 2.5 ug/ml.
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