Home Antibody All anti-ACVR1 antibodies
Also for ACVR1 (NM_001105)
|ACVR1 antibody was raised against a 14 amino acid peptide near the amino terminus of the human ACVR1.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens activin A receptor, type I (ACVR1), transcript variant 1|
|ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI|
Entrez Gene 90 Human
Entrez Gene 11477 Mouse
|Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is associated with polycystic ovary syndrome, suggesting that ACVR1 signaling contributes to disturbed folliculogenesis in these patients. At least four isoforms of ACVR1 are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1B or ACVR1C.|
|Protein KinaseES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionTGF-beta signaling pathway|
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Western blot analysis of ACVR1 in A549 cell lysate with ACVR1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.