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Home Antibody All anti-DARC antibodies

Anti-DARC Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306405
  • Rabbit Polyclonal DARC Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426584) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for DARC (NM_001122951)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenDARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens atypical chemokine receptor 1 (Duffy blood group) (ACKR1), transcript variant 1
Alternative NameCCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1
Database LinkNP_001116423
Entrez Gene 2532 Human
Entrez Gene 13349 Mouse
Entrez Gene 689105 Rat
FunctionDARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
Related PathwayGPCRTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DARC in mouse brain tissue lysate with DARC antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of DARC in mouse brain tissue with DARC antibody at 2.5 ug/ml.

 

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