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Home Antibody All anti-TIGAR antibodies

Anti-TIGAR Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306397 Rabbit Polyclonal TIGAR Antibody 100ug $325 3-7 Days
LC412517 C12orf5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for TIGAR (NM_020375)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenTIGAR antibody was raised against a 18 amino acid peptide from near the center of human TIGAR.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *IHC, WB Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TP53 induced glycolysis regulatory phosphatase (TIGAR)
Alternative NameC12orf5; FR2BP
Database LinkNP_065108
Entrez Gene 57103 Human
Entrez Gene 319801 Mouse
Entrez Gene 502894 Rat
FunctionThe p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


IHC Image
Immunohistochemistry of TIGAR in human brain tissue with TIGAR antibody at 2.5 ug/ml.
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WB Image
Western blot analysis of TIGAR in EL4 cell lysate with TIGAR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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