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Home Antibody All anti-C12orf5 antibodies

Anti-C12orf5 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306397
  • Rabbit Polyclonal TIGAR Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC412517) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for C12orf5 (NM_020375)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTIGAR antibody was raised against a 18 amino acid peptide from near the center of human TIGAR.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens chromosome 12 open reading frame 5 (C12orf5)
Alternative NameFR2BP; TIGAR
Database LinkNP_065108
FunctionThe p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TIGAR in EL4 cell lysate with TIGAR antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of TIGAR in human brain tissue with TIGAR antibody at 2.5 ug/ml.

 

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