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Home Antibody All anti-GPR44 antibodies

Anti-GPR44 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306387
  • Rabbit Polyclonal CRTH2 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401506) , 20ug
100ug $325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenCRTH2 antibody was raised against a 18 amino acid peptide from near the amino terminus of human CRTH2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens prostaglandin D2 receptor 2 (PTGDR2)
Alternative NameCD294; CRTH2; DL1R; DP2; GPR44
Database LinkNP_004769
FunctionThe chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
Related Pathway
Signaling by GPCR

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WB Image
Western blot analysis of CRTH2 in Jurkat cell lysate with CRTH2 antibody at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.
IHC Image
Immunohistochemistry of CRTH2 in human heart tissue with CRTH2 antibody at 2.5 ug/ml.

 

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