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Home Antibody All anti-CLU antibodies

Anti-CLU Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306332
  • Rabbit Polyclonal Clusterin Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC433124) , 20ug
100ug $325 3-7 Days
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WB(1)
IHC(1)
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Also for CLU (NM_001171138)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenClusterin antibody was raised recombinant human Clusterin isoform 1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens clusterin (CLU), transcript variant 3
Alternative NameAAG4; APOJ; CLI; KUB1; MGC24903; SGP-2; SGP2; SP-40; TRPM-2; TRPM2
Database LinkNP_001164609
FunctionClusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer’s b-amyloid peptide (1). Clusterin expression is increased in Alzheimer’s disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites (2) and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression (3). Clusterin exists in at least two distinct isoforms.
Related Pathway
Hemostasis

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WB Image
Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 ug/ml.

 

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