Home Antibody All anti-CASP2 antibodies
Also for CASP2 (NM_001224)
|Caspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 2|
|CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57|
|Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).|
MAPK signaling pathway
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Western blot analysis of caspase-2 in Ramos cells with caspase-2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of caspase-2 in A-20 cells with caspase-2 antibody at 2 ug/mL.