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Anti-CASP2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306194 Rabbit Polyclonal Caspase-2 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenCaspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 2 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 2
Alternative NameCASP-2; ICH1; NEDD-2; NEDD2; PPP1R57
Database LinkNP_001215
Entrez Gene 835 Human
Entrez Gene 12366 Mouse
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of caspase-2 in Ramos cells with caspase-2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.

IF Image
Immunocytochemistry of caspase-2 in A-20 cells with caspase-2 antibody at 2 ug/mL.


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