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Home Antibody All anti-MAP3K7 antibodies

Anti-MAP3K7 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306186
  • Rabbit Polyclonal TAK1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418841) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for MAP3K7 (NM_003188)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTAK1 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the amino-terminus of human TAK1 isoform a.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant A
Alternative NameMEKK7; TAK1; TGF1a
Database LinkNP_003179
FunctionTAK1 (TGF-&betta; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7) (1). It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3 (4,5). Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation (6), while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity (5).
Related Pathway
Adherens junction
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
Wnt Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TAK1 in Rat thymus cell lysate with TAK1 antibody at (A) 1, (B) 2, and (C) 4 µg/ml.

 

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