Home Antibody All anti-XIAP antibodies
Also for XIAP (NM_001167)
|XIAP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.|
||WB: 0.5 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase (XIAP), transcript variant 1|
|API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1; MIHA; XLP2|
Entrez Gene 331 Human
Entrez Gene 11798 Mouse
|Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases (1 for review). The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, and –9 (2,3). Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation; conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation (4). Two negative regulators, termed XAF-1 (5) and Smac (6), can bind and inhibit XIAP activity.|
|Druggable Genome Ubiquitin mediated proteolysisApoptosisFocal adhesionNOD-like receptor signaling pathwayPathways in cancerSmall cell lung cancerMore Pathways >> |
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Western blot analysis of XIAP in human kidney lysate with XIAP antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/ml, respectively.
Immunohistochemical staining of human kidney tissue using XIAP antibody at 2 ug/ml.