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Home Antibody All anti-CARD8 antibodies

Anti-CARD8 Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306138 Rabbit Polyclonal CARD8 Antibody 100ug $325 In Stock
LC433245 CARD8 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(2)
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OriGene Data

ImmunogenCARD8 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARD8.
Clone Name IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase recruitment domain family member 8 (CARD8), transcript variant 1
Alternative NameCARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
Database LinkNP_001171829
Entrez Gene 22900 Human
FunctionApoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis (1,2), and caspase-1 and its related proteins ICEBERG and pesudo-ICE (3). Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein (2,4), it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappaB activation.
Related PathwayDruggable Genome NOD-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of CARD8 expression in K562 cell lysate with CARD8 antibody at (A) 2 and (B) 4 ug /ml.
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IF Image
Immunocytochemistry of CARD8 in K562 cells with CARD8 antibody at 10 ug/mL.
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IF Image
Immunofluorescence of CARD8 in K562 cells with CARD8 antibody at 20 ug/mL.
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