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Home Antibody All anti-ANP32A antibodies

Anti-ANP32A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306127
  • Rabbit Polyclonal PHAP I Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416747) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for ANP32A (NM_006305)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPHAP I antibody was raised with a synthetic peptide corresponding to amino acids close to carboxy terminus of human PHAP I. This sequence is identical between human and rat PHAP I.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A)
Alternative NameC15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32
Database LinkNP_006296
FunctionApoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PHAP I expression in human Raji cell lysate with PHAP antibody I at 2 ug/mL (lane A) and 4 ug/mL (lane B), respectively.
IF Image
Immunocytochemistry of PHAP I in Raji cells with PHAP I antibody at 2 ug/mL.

 

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