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Home Antibody All anti-TBK1 antibodies

Anti-TBK1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306060
  • Rabbit Polyclonal NAK Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC415713) , 20ug
100ug $325 3-7 Days
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IF(1)
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Also for TBK1 (NM_013254)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNAK antibody was raised against a synthetic peptide corresponding to 17 amino acids form near the carboxy terminus of human NAK/TBK1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *IF Suggested DilutionsELISA, WB, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens TANK-binding kinase 1 (TBK1)
Alternative NameNAK; T2K
Database LinkNP_037386
FunctionNuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. Phosphorylation of I-kappaB by IkappaB kinase (IKK) complex leads to degradation of I-kappaB and activation of NF-kappaB. The IKK complex contains IKKalpha, IKKbeta, and IKKgamma. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-kappaB-activating kinase), and T2K (1-3). NAK/TBK1 activates IKKbeta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kappaB activation in response to growth factors (2). NAK/TBK1 functions upstream of NIK and the IKK complex (1,2). NAK/TBK1 is also critical in protecting embryonic liver from apoptosis (3).
Related Pathway
Toll-like receptor signaling pathway

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IF Image
Immunocytochemistry of NAK in MOLT4 cells with NAK antibody at 10 ug/mL.

 

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