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Also for CASP8AP2 (NM_001137667)
|FLASH antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy-terminus of human FLASH which differ from those of mouse by one amino acid.|
||ELISA, WB: 0.5 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript variant 2|
|CED-4; FLASH; RIP25|
|A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). FLASH is widely expressed.|
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Western blot analysis of FLASH in HeLa whole cell lysate with FLASH antibody at 0.5 ug/mL.
Immunocytochemistry of FLASH in HeLa cells with FLASH antibody at 10 ug/mL.