Home Antibody All anti-CFLAR antibodies
Also for CFLAR (NM_001127183)
|FLIP antibody was raised against a peptide corresponding to amino acids near the amino terminus of human FLIP The sequence is identical in all FLIP splice variants.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC, IF: 20 ug/ml, FC
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR), transcript variant 2|
|c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;|
Entrez Gene 8837 Human
Entrez Gene 12633 Mouse
Entrez Gene 117279 Rat
|Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively.|
|ProteaseDruggable Genome Apoptosis|
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Western blot analysis of FLIP in K562 cell lysate with FLIP antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of FLIP in HeLa cells with FLIP antibody at 5 ug/mL.