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Home Antibody All anti-CXCR4 antibodies

Anti-CXCR4 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305935
  • Rabbit Polyclonal CXCR4 Antibody
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenCXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, ICC: 10 ug/ml, IP: 10 ug/ml, IF: 20 ug/ml, FC: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Antibody is DEAE purified

Reference Data

Target NameHomo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1
Alternative NameCD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM
Database LinkNP_001008540
FunctionHuman immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
Related Pathway
Cytokine-cytokine receptor interaction
Signaling by GPCR

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WB Image
Western blot analysis of CXCR4 in HeLa whole cell lysate with CXCR4 antibody at 0.5 ug/ml.
IHC Image
Immunohistochemistry of CXCR4 in HeLa cells with CXCR4 antibody at 2 ug/ml.

 

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