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Home Antibody All anti-GRM7 antibodies

Anti-GRM7 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305625
  • Goat Anti-GRM7 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400295) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenPeptide with sequence NCKLTISGSKKEDT, from the internal region of the protein sequence according to NP_000835.1; NP_870989.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB 0.5-2ug/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens glutamate receptor, metabotropic 7 (GRM7), transcript variant 1
Alternative NameGLUR7; GPRC1G; MGLU7; MGLUR7; PPP1R87
Database LinkNP_000835
Entrez Gene 2917 Human
Entrez Gene 108073 Mouse
Entrez Gene 81672 Rat
FunctionL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayGPCRTransmembraneDruggable Genome Neuroactive ligand-receptor interaction

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WB Image
TA305625 (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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