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Home Antibody All anti-SIAH1 antibodies

Anti-SIAH1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA302689 Goat Polyclonal Antibody against SIAH1 100ug $325 3-7 Days
LC423687 SIAH1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

Immunogen Peptide with sequence SRQTATALPTGTSKC, from the N Terminus of the protein sequence according to NP_003022.3; NP_001006611.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsELISA: 1:32,000. WB: 0.1-0.3µg/ml.
Predicted MW Explanation 34.4 kDa
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

Reference Data

Target NameHomo sapiens siah E3 ubiquitin protein ligase 1 (SIAH1), transcript variant 2
Alternative NameSIAH1A
Database LinkNP_001006611
Entrez Gene 6477 Human
Entrez Gene 140941 Rat
Entrez Gene 100856496 Dog
FunctionThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq].
Related PathwayDruggable Genome p53 signaling pathwayUbiquitin mediated proteolysisWnt signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

TA302689 staining (0.1µg/ml) of Human Liver lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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