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Home Antibody All anti-DDR1 antibodies

Anti-DDR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA302034
  • Rabbit Polyclonal Antibody against DDR1 (Center)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400719) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)
IF(1)
FC(1)

OriGene Data

ImmunogenThis DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-330 amino acids from the Central region of human DDR1.
Clone Name IsotypeRabbit Ig
Species ReactivityHuman Concentration0.25 mg/ml
Guaranteed Application *WB, IHC, IF, FC Suggested DilutionsWB: 1:1000, IHC: 1:10~50, IF: 1:10~50, FC: 1:10~50
Predicted MW Explanation 101128 Da
BufferPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reference Data

Target NameHomo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 1
Alternative NameCAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
Database LinkNP_001945
Entrez Gene 780 Human
FunctionReceptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
Related PathwayProtein KinaseTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of DDR1 (arrow) using rabbit polyclonal DDR1 Antibody (Center)(Cat.#TA302034).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DDR1 gene (Lane 2) (Origene Technologies).
IHC Image
DDR1 Antibody (Center) (Cat. #TA302034)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DDR1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
IF Image
Confocal immunofluorescent analysis of DDR1 Antibody (Center)(Cat#TA302034) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
FC Image
DDR1 Antibody (Center) (Cat. #TA302034) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

 

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