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Home Antibody All anti-ARNT antibodies

Anti-ARNT Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301442
  • Rabbit Polyclonal Antibody against HIF-1 beta
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400636) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for ARNT (NM_001668)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein to human HIF-1 beta. Containing a.a. 496-789.
Clone Name IsotypeIgG
Species Reactivityhuman, bovine, sheep, mouse, rat, ferret ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000
Buffer0.02% sodium azide
Purification Whole antisera

Reference Data

Target NameHomo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1
Alternative NamebHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Database LinkNP_001659
Entrez Gene 405 Human
Entrez Gene 11863 Mouse
Entrez Gene 25242 Rat
FunctionHypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. (1,5,6)
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western Blot: HIF-1 beta Antibody TA301442 - WB analysis of HIF-1 beta in MCF7 whole cell lysate.
IHC Image
Staining of skin, epidermis.

 

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