OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-CUL1 antibodies

Anti-CUL1 Antibody EPR3102Y

div

Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA301269
  • Rabbit Monoclonal Antibody against CUL1 (Clone EPR3102Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418561) , 20ug Explanation
100ul $325 3-7 Days
Add to Shopping Cart
spacer
WB(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CUL1 was used as an immunogen.
Clone NameEPR3102Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1: 1000~2000; ICC: 1: 100~250; FC: 1:80
Predicted MW Explanation 90 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens cullin 1 (CUL1)
Alternative NameMGC149834; MGC149835
Database LinkNP_003583
Entrez Gene 8454 Human
Entrez Gene 26965 Mouse
Entrez Gene 362356 Rat
FunctionCullin proteins assemble a large number of RING E3 ubiquitin ligases and regulate various physiological processes (1). It has been shown that the SKP1, CUL1, F-box (SCF) containing pathway, although similarly used by the mammalian CUL1, is not shared by other cullin members. This implies that most cullins may use a SKP1/F-box-independent pathway to facilitate protein degradation (2). The majority of CUL1 has been found in a complex with CAND1 and ROC1, independent of SKP1 and F-box protein SKP2. Data suggests that CAND1 regulates the formation of the SCF complex, and its dissociation from CUL1 is coupled with the incorporation of F-box proteins into the SCF complex, causing their destabilization (3).
Related PathwayDruggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisWnt signaling pathwayTGF-beta signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Cullin 1 antibody [EPR3102Y]; All lanes : Anti-Cullin 1 antibody [EPR3102Y] at 1/2000 dilution.Lane 1 : 293T cell lysate.Lane 2 : A549 cell lysate.Lane 3 : T47D cell lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 90 kDa.Observed band size : 90 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Cullin 1 antibody [EPR3102Y]; TA301269 at 1/100 dilution staining Cullin 1 in HeLa cells by Immunofluorescence.

 

spacer
Inc 5000 Healthcare Company Copyright © 2015 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title