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Home Antibody All anti-CAMK4 antibodies

Anti-CAMK4 Antibody EP2564Y


Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against CAMK4 (Clone EP2564Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400661) , 20ug Explanation
100ul 325 3-7 Days
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Also for CAMK4 (NM_001744)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human CaMKIV was used as an immunogen.
Clone NameEP2564Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000; ICC: 1: 100~250
Predicted MW Explanation 52 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens calcium/calmodulin-dependent protein kinase IV (CAMK4)
Alternative NamecaMK; CaMK IV; CaMK-GR; IV
Database LinkNP_001735
Entrez Gene 814 Human
Entrez Gene 12326 Mouse
Entrez Gene 25050 Rat
FunctionCa(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a multifunctional protein kinase expressed abundantly in the central nervous system. Because changes in intracellular Ca(2+) concentrations affect progression through the mitotic cell cycle, enhanced expression of CaMKIV has been reported in small cell lung carcinoma and hepatocellular carcinoma (1). Multifunctional Ca2+/calmodulin kinase IV is enriched in neurons and T lymphocytes. The kinase is absent from primary human B lymphocytes but is expressed in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell lines, suggesting that expression of the kinase can be upregulated by an EBV gene products. In view of the key role played by LMP1 in B-lymphocyte immortalization by EBV, findings implicate Ca2+/calmodulin kinase IV as a potential mediator of B-lymphocyte growth transformation (2). Ca2+/calmodulin kinase IV can suppress the MT-regulating activity of Op18 by phosphorylation on Ser-16. These results show that Op18 phosphorylation by Ca2+/calmodulin kinase IV may couple alterations of MT dynamics in response to external signals that involve Ca2+ (3).
Related PathwayProtein KinaseDruggable Genome Calcium signaling pathwayLong-term potentiationNeurotrophin signaling pathway

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WB Image
Western blot - CAMKIV antibody [EP2564Y]; All lanes : Anti-CAMKIV antibody [EP2564Y] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Human brain lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/1000 dilution.Predicted band size : 52 kDa.Observed band size : 60 kDa .


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