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Home Antibody All anti-HSPA8 antibodies

Anti-HSPA8 Antibody EP1531Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300865
  • Rabbit Monoclonal Antibody against HSPA8 (Clone EP1531Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401978) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for HSPA8 (NM_006597)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Hsp73 was used as an immunogen.
Clone NameEP1531Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsFC: 1:30; IP: 1:10; WB: 1:500; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens heat shock 70kDa protein 8 (HSPA8), transcript variant 1
Alternative NameHEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71
Database LinkNP_006588
FunctionHsp73 is a normal cell constituent which is synthesized in increased abundance under adverse environmental circumstances, such as non-physiological temperatures or treatment with amino acid analogues (1). Data has shown a molecular mechanism for cytokine-mediated posttranscriptional regulation of Bim mRNA by Hsc70, which binds to AU-rich elements (AREs) in the 3'-untranslated region of specific mRNAs and enhances their stability. The RNA binding potential of Hsc70 is regulated by cochaperones including Bag-4 (also SODD), CHIP, Hip, and Hsp40 (2). Hsp73 protein expression was detected in the cytoplasm of melanoma cells in primary tumors and metastases. In primary melanomas, the proportion of Hsp73 protein expressing cells correlated with tumor thickness which was found to be statistically significant (3).
Related Pathway
MAPK signaling pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - Hsc70 antibody [EP1531Y]; Anti-Hsc70 antibody [EP1531Y] at 1/500 dilution + HeLa cell lysate at 10 µg.Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 71 kDa.Observed band size : 71 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Hsc70 antibody [EP1531Y]; Ab51052 (1/250) staining Hsc70 in paraffin embedded human breast carcinoma tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - Hsc70 antibody [EP1531Y]; Immunofluorescent staining of HeLa cells using TA300865 (1/100).

 

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