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Anti-STK3 Antibody EP1466Y


Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
TA300843 Rabbit Monoclonal Antibody against STK3 (Clone EP1466Y) 100ul $325 In Stock
LC401892 STK3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus of human Mst2 was used as an immunogen.
Clone NameEP1466Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1:50 100; ICC: 1: 100 250; IP: 1: 100
Predicted MW Explanation 56 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens serine/threonine kinase 3 (STK3), transcript variant 1
Alternative NameKRS1; MST2
Database LinkNP_006272
Entrez Gene 6788 Human
Entrez Gene 56274 Mouse
Entrez Gene 65189 Rat
FunctionMammalian Sterile 20-Like 2 (Mst2) is most similar to the previously identified Mst1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in-vitro kinase assay indicates that Mst2 can phosphorylate an exogenous substrate, as well as itself, and phospho-amino-acid analysis indicates that it is a serine/threonine protein kinase (1) Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2. Results indicate that Mst2-like kinases regulate Lats kinase activities in an evolutionarily conserved regulatory pathway (2). When stably expressed in HeLa cells, Mst highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that Mst1 and Mst2 play a role in apoptosis both upstream and downstream of caspase activation (3).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - STK3 antibody [EP1466Y]; Anti-STK3 antibody [EP1466Y] at 1/10000 dilution + C6 cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 56 kDa.Observed band size : 56 kDa.
Immunohistochemistry (Paraffin-embedded sections) - STK3 antibody [EP1466Y]; Human lymphoma stained with TA300843 at 1/50 - 1/100 dilution


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