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Home Antibody All anti-STK4 antibodies

Anti-STK4 Antibody EP1465Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300841
  • Rabbit Monoclonal Antibody against STK4 (Clone EP1465Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401893) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for STK4 (NM_006282)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Mst1 was used as an immunogen.
Clone NameEP1465Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1: 100 250; ICC: 1: 100 250; FC: 1: 100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens serine/threonine kinase 4 (STK4)
Alternative NameKRS2; MST1; TIIAC; YSK3
Database LinkNP_006273
FunctionThe human serine/threonine kinase, mammalian STE20-like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation (1). MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression (2). Mst1 can phosphorylate H2B at S14 in vitro and in vivo, and the onset of H2B S14 phosphorylation is dependent upon cleavage of Mst1 by caspase-3. These data reveal a histone modification that is uniquely associated with apoptotic chromatin in species ranging from frogs to humans and provide insights into a previously unrecognized physiological substrate for Mst1 kinase (3).
Related Pathway
MAPK signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MST1 antibody [EP1465Y]; Anti-MST1 antibody [EP1465Y] at 1/10000 dilution + HeLa cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 56 kDa.Observed band size : 59 kDa .</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - MST1 antibody [EP1465Y]; Ab51134 (1:100) staining human MST1 in human urinary bladder tissue by immunohistochemistry using paraffin embedded tissue.</title><style>.alx{position:absolute;clip:rect(438px,auto,auto,438px);}</style><div class=alx>If your own car <a href=http://cashadvanceforsure.com >approved cash advance</a> contact your credit pay period.</div>

 

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